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dc.contributor.authorKorulu, Şirinen_US
dc.contributor.authorYıldız, Ayşegülen_US
dc.date.accessioned2020-08-21T11:48:12Z
dc.date.available2020-08-21T11:48:12Z
dc.date.issued2020en_US
dc.identifier.citationKorulu, S., & Yildiz, A. (2020). p60-katanin: a novel interacting partner for p53. Molecular Biology Reports, 47(6), 4295-4301. doi:10.1007/s11033-020-05557-6en_US
dc.identifier.issn0301-4851
dc.identifier.issn1573-4978
dc.identifier.urihttp://dx.doi.org/10.1007/s11033-020-05557-6
dc.identifier.urihttps://hdl.handle.net/20.500.12294/2512
dc.description.abstractKatanin, one of the best-characterized microtubule (MT) severing proteins, is composed of two subunits: catalytic p60-katanin, and regulatory p80-katanin. p60-katanin triggers MT reorganization by severing them. MT reorganization is essential for both mitotic cells and post-mitotic neurons in numerous vital processes such as intracellular transport, mitosis, cellular differentiation and apoptosis. Due to the deleterious effect of continuous severing for cells, p60-katanin requires a strategic regulation. However, there are only a few known regulators of p60-katanin. p53 functions in similar cellular processes as katanin such as cell cycle, differentiation, and apoptosis depending on its interacting partners. Considering this similarity, in this study we investigated p53 as a potential regulatory candidate of p60-katanin, and examined their interaction. Co-immunoprecipitation analyses revealed that p60-katanin interacts with p53. We were able to locate a potential interaction site for the two proteins by deleting different candidate regions We showed for the first time that p53 and p60-katanin interact. This interaction appears to occur via p53's DNA binding domain and p60-katanin's C-terminal. This study will pave the way for future studies regarding the functional outcomes of this interaction which is vital for understanding the regulation of cellular events such as cell cycle, differentiation, and apoptosis in disease and in health.en_US
dc.language.isoengen_US
dc.publisherSpringeren_US
dc.relation.ispartofMolecular Biology Reportsen_US
dc.identifier.doi10.1007/s11033-020-05557-6en_US
dc.identifier.doi10.1007/s11033-020-05557-6
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectP60-Kataninen_US
dc.subjectP53en_US
dc.subjectProtein-Protein Interactionen_US
dc.subjectMicrotubule Related Proteinsen_US
dc.titlep60-katanin: a novel interacting partner for p53en_US
dc.typearticleen_US
dc.departmentFen-Edebiyat Fakültesi, Moleküler Biyoloji ve Genetik Bölümüen_US
dc.identifier.volume47en_US
dc.identifier.issue6en_US
dc.identifier.startpage4295en_US
dc.identifier.endpage4301en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.relation.tubitakinfo:eu-repo/grantAgreement/TUBITAK/SOBAG/114Z971


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