• Chemical Characterization of Different Extracts from Artemisia annua and Their Antioxidant, Enzyme Inhibitory and Anti-Inflammatory Properties 

  Acquaviva, Alessandra; Nilofar; Bouyahya, Abdelhakim; Zengin, Gokhan; Di Simone, Simonetta Cristina; Recinella, Lucia; Leone, Sheila; Brunetti, Luigi; Uba, Abdullahi Ibrahim; Cakilcioğlu, Ugur; Polat, Rıdvan; Darendelioglu, Ekrem (John Wiley and Sons Inc, 2023)

  Artemisia annua L. (Asteraceae Family) is an important plant in Asia that has been used for treating different diseases, including fever due to malaria, wounds, tubercolisis, scabues, pain, convulsions, diabetes, and ...

• Chemical characterization and biological abilities of Anthocleista djalonensis collected from two locations of Ivory Coast 

  Sinan, Kouadio Ibrahime; Zengin, Gokhan; Uba, Abdullahi Ibrahim; Caprioli, Giovanni; Angeloni, Simone; Vittori, Sauro; Jugreet, Sharmeen; Etienne, Ouattara Katinan; Shariati, Mohamad Ali; Mahomoodally, Mohamad Fawzi (John Wiley and Sons Inc, 2023)

  In this study, the total phenolic and flavonoid contents, HPLC-DAD detected phytochemicals, antioxidant and enzyme inhibitory potential of methanolic and aqueous (as infusion) extracts of the medicinal plant, Anthocleista ...

• In the quest for histone deacetylase inhibitors: current trends in the application of multilayered computational methods 

  Zengin, Gokhan (SPRINGER WIEN, 2023)

  Histone deacetylase (HDAC) inhibitors have gained attention over the past three decades because of their potential in the treatment of different diseases including various forms of cancers, neurodegenerative disorders, ...

• In Vitro and Molecular Docking Evaluation of Larvicidal Effects of Essential Oils of Five Aromatic Plants on the Fall Armyworm Spodoptera frugiperda JE. Smith (Lepidoptera: Noctuidae) from Ivory Coast 

  Kobenan, Koffi Christophe; Kouadio, Ibrahime Sinan; Kouakou, Malanno; Silvie, Pierre; Kouadio, Kra Norbert Bini; N'goran, Kouadio Emmanuel; Kouakou, Brou Julien; Amangoua, Nogbou Ferdinand; Tehia, Kouakou Etienne; Uba, Abdullahi Ibrahim; Zengin, Gokhan (WILEY-V C H VERLAG GMBH, 2023)

  Faced with the serious consequences resulting from the abusive and repeated use of synthetic chemicals, today rethinking crop protection is more than necessary. It is in this context that the essential oils of the Lamiaceae ...

• Bacteriophage genome engineering for phage therapy to combat bacterial antimicrobial resistance as an alternative to antibiotics 

  Usman, Sani Sharif; Uba, Abdullahi Ibrahim; Christina, Evangeline (SPRINGER, 2023)

  Bacteriophages (phages) are viruses that mainly infect bacteria and are ubiquitously distributed in nature, especially to their host. Phage engineering involves nucleic acids manipulation of phage genome for antimicrobial ...

• Unraveling the chemical profile, antioxidant, enzyme inhibitory, cytotoxic potential of different extracts from Astragalus caraganae 

  Kurt-Celep, Inci; Zengin, Gokhan; Uba, Abdullahi I.; Caprioli, Giovanni; Mustafa, Ahmed M.; Angeloni, Simone; Cakilcioglu, Ugur; Guler, Osman; Kaplan, Alevcan; Sharmeen, Jugreet; Mahomoodally, Mohamad F. (WILEY-V C H VERLAG GMBH, 2023)

  Six extracts (water, ethanol, ethanol-water, ethyl acetate, dichloromethane, and n-hexane) of Astragalus caraganae were studied for their biological activities and bioactive contents. Based on high-performance liquid ...

• Comparative GC-MS Analysis of Fresh and Dried Curcuma Essential Oils with Insights into Their Antioxidant and Enzyme Inhibitory Activities 

  Fahmy, Nouran M.; Fayez, Shaimaa; Uba, Abdullahi Ibrahim; Shariati, Mohammad Ali; Aljohani, Abdullah S. M.; El-Ashmawy, Ibrahim M.; Batiha, Gaber El-Saber; Eldahshan, Omayma A.; Singab, Abdel Nasser; Zengin, Gokhan (MDPI, 2023)

  Species belonging to the Zingiberaceae family are of high nutritional, industrial, and medicinal values. In this study, we investigated the effect of processing steps (fresh vs. dried milled rhizomes) and extraction ...

• Rapid and efficient ambient temperature X-ray crystal structure determination at Turkish Light Source 

  Gul, Mehmet; Ayan, Esra; Destan, Ebru; Johnson, J. Austin; Shafiei, Alaleh; Kepceoğlu, Abdullah; Yilmaz, Merve; Ertem, Fatma Betül; Yapici, İlkin; Tosun, Bilge; Baldir, Nilüfer; Tokay, Nurettin; Arslan, Nazlı Eylül (Nature Research, 2023)

  High-resolution biomacromolecular structure determination is essential to better understand protein function and dynamics. Serial crystallography is an emerging structural biology technique which has fundamental limitations ...

• Computational analysis of drug resistance of taxanes bound to human β-tubulin mutant (D26E) 

  Uba, Abdullahi Ibrahim; Bui-Linh, Candice; Thornton, Julianne M.; Olivieri, Michael; Wu, Chun (Elsevier Inc., 2023)

  The single-point mutation D26E in human β-tubulin is associated with drug resistance seen with two anti-mitotic taxanes (paclitaxel and docetaxel) when used to treat cancers. The molecular mechanism of this resistance ...

• Expression of genes related to iron homeostasis in breast cancer 

  Mutlu, Tuba; Ozoran, Emre; Trabulus, Didem Can; Talu, Canan Kelten; Erhan, Duygu; Mete, Meltem; Guven, Mehmet (SPRINGER, 2023)

  Background The dysfunctions in the metabolism of iron have an important role in many pathological conditions, ranging from disease with iron deposition to cancer. Studies on malignant diseases of the breast reported irregular ...

• Phenolic compounds as histone deacetylase inhibitors: binding propensity and interaction insights from molecular docking and dynamics simulations 

  Uba, Abdullahi Ibrahim; Zengin, Gokhan (SPRINGER WIEN, 2023)

  Histone deacetylases are well-established target enzymes involved in the pathology of different diseases including cancer and neurodegenerative disorders. The approved HDAC inhibitor drugs are associated with cellular ...

• Adding New Scientific Evidences on the Pharmaceutical Properties of Pelargonium quercetorum Agnew Extracts by Using In Vitro and In Silico Approaches 

  Chiavaroli, Annalisa; Libero, Maria Loreta; Di Simone, Simonetta Cristina; Acquaviva, Alessandra; Nilofar, Lucia; Uba, Abdullahi Ibrahim (MDPI, 2023)

  Pelargonium quercetorum is a medicinal plant traditionally used for treating intestinal worms. In the present study, the chemical composition and bio-pharmacological properties of P. quercetorum extracts were investigated. ...

• İnsan p60-katanin Proteininin, Bitki RIC1 ve İnsan Homoloğu Kiaa1432 Proteinleri ile Etkileşiminin Tespiti & Etkileşimin Mikrotubuller Üzerinde Fonksiyonel Analizi 

  Korulu, Şirin Koç; Selçuk, İlke; Kurtoğlu, Ceren (TÜBİTAK KBAG Proje, 2023)

  Mikrotubuller ihtiyaç durumuna göre uzayıp–kısalabilen, yeniden organize olabilen dinamik yapılı polimerlerdir. Mikrotubul organizasyonu, bölünen hücrelerde mitoz, post-mitotik nöronlarda akson/dendrit yapılarının ...

• Aktif Bölge Mimarisinin Anlaşılması Temelinde, NAD + Bağımlı Mutant Candida methylica Format Dehidrogenaz Enziminin Spesifik Aktivitesinin Arttırılması 

  Binay, Barış; Torun, Soner (TÜBİTAK KBAG Proje, 2023)

  Format dehidrogenaz enzimi (FDH), endüstriyel biyokatalizörler arasında son yıllarda en çok dikkat çeken enzimlerden biridir. Özellikle NAD(P)+ bağımlı FDH, gerçekleştirdiği reaksiyonun düşük redoks potansiyeli nedeniyle ...

• Chemical Characterization and Multidirectional Biological Effects of Different Solvent Extracts of Arum elongatum: in Vitro and in Silico Approaches 

  Fawzi Mahomoodally, Mohamad; Zengin, Gokhan; Roumita, Seebaluck-Sandoram; Caprioli, Giovanni; Mustafa, Ahmed M.; Piatti, Diletta; Yildiztugay, Evren; Ak, Gunes; Esra Karadag, Ayse; Khalid, Asaad; Abdalla, Ashraf N.; Ibrahim Uba, Abdullahi; Demirci, Fatih (WILEY-V C H VERLAG GMBH, 2023)

  Arum elongatum (Araceae) is widely used traditionally for the treatment of abdominal pain, arterial hypertension, diabetes mellitus, rheumatism and hemorrhoids. This study investigated the antioxidant properties, individual ...

• Gene therapy in haemophilia: literature review and regional perspectives for Turkey 

  Kavakli, Kaan; Antmen, Bulent; Okan, Vahap; Sahin, Fahri; Aytac, Selin; Balkan, Can; Berber, Ergul; Kaya, Zuhre; Kupesiz, Alphan; Zulfikar, Bulent (SAGE Publications Ltd, 2022)

  Haemophilia is an X-linked lifelong congenital bleeding disorder that is caused by insufficient levels of factor VIII (FVIII; haemophilia A) or factor IX (FIX; haemophilia B) and characterized by spontaneous and trauma-related ...

• In Silico Analysis of SARS-CoV-2 Spike Protein N501Y and N501T Mutation Effects on Human ACE2 Binding 

  Çubuk, Hasan; Özbi·l, Mehmet (Elsevier Inc., 2022)

  The SARS-CoV-2 is an RNA-based virus and the most vital step of its survival is the attachment to hACE2 through its spike protein. Although SARS-CoV-2 has the ability to maintain high accurate replication and it can be ...

• Epigenetics in Bladder Cancer: A Review of the Literature 

  Doğan, Tunay; Yazıcı, Hülya (Kare Publishing, 2021)

  Bladder cancer (BC) is the 10th most frequent type of cancer worldwide, with around 549.000 new cases and 200.000 deaths/year and it has the highest incidence rates with a strong male and elderly predominance. Besides, BC ...

• Synthesis, Characterization and Biocompatibility Oo Plant-Oil Based Hydrogels 

  Yalçın Çapan, Özlem; Çakır Hatır, Pınar (Trakya University, 2021)

  Biocompatible hydrogels are used in a variety of biomedical applications, including tissue scaffolds, drug delivery systems, lab/organ-on-a-chips, biosensors, cell-culture studies and contact lenses. The demand for novel ...

• Comparison of Clinically Approved Molecules on SARS-CoV-2 Drug Target proteins: A Molecular Docking Study 

  Çubuk, Hasan; Özbil, Mehmet (TUBITAK, 2021)

  The new type of coronavirus, SARS-CoV-2 has affected more than 22.6 million people worldwide. Since the first day the virus was spotted in Wuhan, China, numerous drug design studies have been conducted all over the globe. ...

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