• Chemical Characterization of Different Extracts from Artemisia annua and Their Antioxidant, Enzyme Inhibitory and Anti-Inflammatory Properties 

  Acquaviva, Alessandra; Nilofar; Bouyahya, Abdelhakim; Zengin, Gokhan; Di Simone, Simonetta Cristina; Recinella, Lucia; Leone, Sheila; Brunetti, Luigi; Uba, Abdullahi Ibrahim; Cakilcioğlu, Ugur; Polat, Rıdvan; Darendelioglu, Ekrem (John Wiley and Sons Inc, 2023)

  Artemisia annua L. (Asteraceae Family) is an important plant in Asia that has been used for treating different diseases, including fever due to malaria, wounds, tubercolisis, scabues, pain, convulsions, diabetes, and ...

• Chemical characterization and biological abilities of Anthocleista djalonensis collected from two locations of Ivory Coast 

  Sinan, Kouadio Ibrahime; Zengin, Gokhan; Uba, Abdullahi Ibrahim; Caprioli, Giovanni; Angeloni, Simone; Vittori, Sauro; Jugreet, Sharmeen; Etienne, Ouattara Katinan; Shariati, Mohamad Ali; Mahomoodally, Mohamad Fawzi (John Wiley and Sons Inc, 2023)

  In this study, the total phenolic and flavonoid contents, HPLC-DAD detected phytochemicals, antioxidant and enzyme inhibitory potential of methanolic and aqueous (as infusion) extracts of the medicinal plant, Anthocleista ...

• In the quest for histone deacetylase inhibitors: current trends in the application of multilayered computational methods 

  Zengin, Gokhan (SPRINGER WIEN, 2023)

  Histone deacetylase (HDAC) inhibitors have gained attention over the past three decades because of their potential in the treatment of different diseases including various forms of cancers, neurodegenerative disorders, ...

• In Vitro and Molecular Docking Evaluation of Larvicidal Effects of Essential Oils of Five Aromatic Plants on the Fall Armyworm Spodoptera frugiperda JE. Smith (Lepidoptera: Noctuidae) from Ivory Coast 

  Kobenan, Koffi Christophe; Kouadio, Ibrahime Sinan; Kouakou, Malanno; Silvie, Pierre; Kouadio, Kra Norbert Bini; N'goran, Kouadio Emmanuel; Kouakou, Brou Julien; Amangoua, Nogbou Ferdinand; Tehia, Kouakou Etienne; Uba, Abdullahi Ibrahim; Zengin, Gokhan (WILEY-V C H VERLAG GMBH, 2023)

  Faced with the serious consequences resulting from the abusive and repeated use of synthetic chemicals, today rethinking crop protection is more than necessary. It is in this context that the essential oils of the Lamiaceae ...

• Unraveling the chemical profile, antioxidant, enzyme inhibitory, cytotoxic potential of different extracts from Astragalus caraganae 

  Kurt-Celep, Inci; Zengin, Gokhan; Uba, Abdullahi I.; Caprioli, Giovanni; Mustafa, Ahmed M.; Angeloni, Simone; Cakilcioglu, Ugur; Guler, Osman; Kaplan, Alevcan; Sharmeen, Jugreet; Mahomoodally, Mohamad F. (WILEY-V C H VERLAG GMBH, 2023)

  Six extracts (water, ethanol, ethanol-water, ethyl acetate, dichloromethane, and n-hexane) of Astragalus caraganae were studied for their biological activities and bioactive contents. Based on high-performance liquid ...

• Comparative GC-MS Analysis of Fresh and Dried Curcuma Essential Oils with Insights into Their Antioxidant and Enzyme Inhibitory Activities 

  Fahmy, Nouran M.; Fayez, Shaimaa; Uba, Abdullahi Ibrahim; Shariati, Mohammad Ali; Aljohani, Abdullah S. M.; El-Ashmawy, Ibrahim M.; Batiha, Gaber El-Saber; Eldahshan, Omayma A.; Singab, Abdel Nasser; Zengin, Gokhan (MDPI, 2023)

  Species belonging to the Zingiberaceae family are of high nutritional, industrial, and medicinal values. In this study, we investigated the effect of processing steps (fresh vs. dried milled rhizomes) and extraction ...

• Rapid and efficient ambient temperature X-ray crystal structure determination at Turkish Light Source 

  Gul, Mehmet; Ayan, Esra; Destan, Ebru; Johnson, J. Austin; Shafiei, Alaleh; Kepceoğlu, Abdullah; Yilmaz, Merve; Ertem, Fatma Betül; Yapici, İlkin; Tosun, Bilge; Baldir, Nilüfer; Tokay, Nurettin; Arslan, Nazlı Eylül (Nature Research, 2023)

  High-resolution biomacromolecular structure determination is essential to better understand protein function and dynamics. Serial crystallography is an emerging structural biology technique which has fundamental limitations ...

• Computational analysis of drug resistance of taxanes bound to human β-tubulin mutant (D26E) 

  Uba, Abdullahi Ibrahim; Bui-Linh, Candice; Thornton, Julianne M.; Olivieri, Michael; Wu, Chun (Elsevier Inc., 2023)

  The single-point mutation D26E in human β-tubulin is associated with drug resistance seen with two anti-mitotic taxanes (paclitaxel and docetaxel) when used to treat cancers. The molecular mechanism of this resistance ...

• Expression of genes related to iron homeostasis in breast cancer 

  Mutlu, Tuba; Ozoran, Emre; Trabulus, Didem Can; Talu, Canan Kelten; Erhan, Duygu; Mete, Meltem; Guven, Mehmet (SPRINGER, 2023)

  Background The dysfunctions in the metabolism of iron have an important role in many pathological conditions, ranging from disease with iron deposition to cancer. Studies on malignant diseases of the breast reported irregular ...

• Phenolic compounds as histone deacetylase inhibitors: binding propensity and interaction insights from molecular docking and dynamics simulations 

  Uba, Abdullahi Ibrahim; Zengin, Gokhan (SPRINGER WIEN, 2023)

  Histone deacetylases are well-established target enzymes involved in the pathology of different diseases including cancer and neurodegenerative disorders. The approved HDAC inhibitor drugs are associated with cellular ...

• Adding New Scientific Evidences on the Pharmaceutical Properties of Pelargonium quercetorum Agnew Extracts by Using In Vitro and In Silico Approaches 

  Chiavaroli, Annalisa; Libero, Maria Loreta; Di Simone, Simonetta Cristina; Acquaviva, Alessandra; Nilofar, Lucia; Uba, Abdullahi Ibrahim (MDPI, 2023)

  Pelargonium quercetorum is a medicinal plant traditionally used for treating intestinal worms. In the present study, the chemical composition and bio-pharmacological properties of P. quercetorum extracts were investigated. ...

• Chemical Characterization and Multidirectional Biological Effects of Different Solvent Extracts of Arum elongatum: in Vitro and in Silico Approaches 

  Fawzi Mahomoodally, Mohamad; Zengin, Gokhan; Roumita, Seebaluck-Sandoram; Caprioli, Giovanni; Mustafa, Ahmed M.; Piatti, Diletta; Yildiztugay, Evren; Ak, Gunes; Esra Karadag, Ayse; Khalid, Asaad; Abdalla, Ashraf N.; Ibrahim Uba, Abdullahi; Demirci, Fatih (WILEY-V C H VERLAG GMBH, 2023)

  Arum elongatum (Araceae) is widely used traditionally for the treatment of abdominal pain, arterial hypertension, diabetes mellitus, rheumatism and hemorrhoids. This study investigated the antioxidant properties, individual ...

• Synthesis, Characterization and Biocompatibility Oo Plant-Oil Based Hydrogels 

  Yalçın Çapan, Özlem; Çakır Hatır, Pınar (Trakya University, 2021)

  Biocompatible hydrogels are used in a variety of biomedical applications, including tissue scaffolds, drug delivery systems, lab/organ-on-a-chips, biosensors, cell-culture studies and contact lenses. The demand for novel ...

• Comparison of Clinically Approved Molecules on SARS-CoV-2 Drug Target proteins: A Molecular Docking Study 

  Çubuk, Hasan; Özbil, Mehmet (TUBITAK, 2021)

  The new type of coronavirus, SARS-CoV-2 has affected more than 22.6 million people worldwide. Since the first day the virus was spotted in Wuhan, China, numerous drug design studies have been conducted all over the globe. ...

• HNF1A-MODY Mutations in Nuclear Localization Signal Impair HNF1A-Import Receptor KPNA6 Interactions 

  Fareed, Fareed M. A.; Korulu, Şirin; Özbil, Mehmet; Çapan Yalçın, Özlem (Springer, 2021)

  Mutations in hepatocyte nuclear factor (HNF)1A gene cause the most common form of Maturity-onset diabetes of the young (MODY), a monogenic subtype of diabetes mellitus. Functional characterization of mutant proteins reveals ...

• Whole exome sequencing reveals novel candidate gene variants for MODY 

  Çapan Yalçın, Özlem; Aydın, Neslihan; Yılmaz, Temel; Berber, Ergül (Elsevier, 2020)

  Maturity-onset diabetes of the young (MODY) is a monogenic subtype of diabetes mellitus. Although 14 genes were associated to different subtypes of MODY, 30-40% of MODY patients have unidentified genetic mutations. In this ...

• p60-katanin: a novel interacting partner for p53 

  Korulu, Şirin; Yıldız, Ayşegül (Springer, 2020)

  Katanin, one of the best-characterized microtubule (MT) severing proteins, is composed of two subunits: catalytic p60-katanin, and regulatory p80-katanin. p60-katanin triggers MT reorganization by severing them. MT ...

• Novel N-(1-thia-4-azaspiro[4.5]decan-4-yl)carboxamide derivatives as potent and selective influenza virus fusion inhibitors 

  Göktaş, Füsun; Özbil, Mehmet; Cesur, Nesrin; Vanderlinden, Evelien; Naesens, Lieve; Cesur, Zafer (Wiley, 2019)

  Hemagglutinin is the surface protein of the influenza virus that mediates both binding and penetration of the virus into host cells. We here report on the synthesis and structure-activity relationship of some novel ...

• Characterization of a new acidic NAD(+)-dependent formate dehydrogenase from thermophilic fungus Chaetomium thermophilum 

  Özgün, Gülşah; Karagüler, Nevin Gül; Turunen, Ossi; Turner, Nicholas J.; Binay, Barış (ELSEVIER SCIENCE BV, 2015)

  NAD(+)-dependent formate dehydrogenase (FDH) enzyme catalyses the NAD(P)(+)-dependent interconversion of formate anion to carbon dioxide coupled with the conversion of NAD(P)(+) to NAD(P)H. NADH is widely used as cofactor ...

• De novo 8p23.1 deletion in a patient with absence epilepsy 

  Akçakaya, Nihan Hande; Çapan Yalçın, Özlem; Schulz, Herbert; Sander, Thomas; Çağlayan, Server Hande; Yapıcı, Zuhal (John Libbey Eurotext, 2017)

  The 8p23.1 deletion syndrome is a rare multisystem disorder with high penetrance and a variable phenotypic spectrum that includes congenital heart disease (CHD), intellectual disability, behavioural problems, microcephalia, ...

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