https://hdl.handle.net/20.500.12294/741 Faculty of Communication 2026-04-11T20:03:09Z https://hdl.handle.net/20.500.12294/4103 Synthesis of novel coumarin-triazole hybrids and first evaluation of the 4-phenyl substituted hybrid loaded PLGA nanoparticles delivery system to the anticancer activity Arvas, Busra; Ucar, Burcu; Acar, Tayfun; Varli, Hanife Sevgi; Arvas, Melih Besir; Aydogan, Feray; Yolacan, Cigdem Despite the discovery of many chemotherapeutic drugs that prevent uncontrolled cell division processes in the last century, many studies are still being carried out to develop drugs with higher anticancer efficacy and lower level of side effects. Herein, we designed, synthesized, and characterized six novel coumarin-triazole hybrids, and evaluated for anticancer activity of the one with the highest potential against the breast cancer cell line, MCF-7 and human cervical cancer cell line, human cervical adenocarcinoma (HeLa). Compound 21 which was the coumarin derivative including phenyl substituent with the lowest IC50 value displayed the highest cytotoxicity against the studied cancer cell line. Furthermore, the potential use of poly (lactic-co-glycolic acid) nanoparticles (PLGA NPs) prepared by the emulsifying solvent evaporation method as a platform for a drug delivery system was studied on a selected coumarin derivative 21. This coumarin derivative-loaded PLGA NPs were produced with an average size of 225.90 +/- 2.96 nm, -16.90 +/- 0.85 mV zeta potential, and 4.12 +/- 0.90% drug loading capacity. The obtained 21-loaded PLGA nanoparticles were analyzed spectroscopically and microscopically with FT-IR, UV-vis, and scanning electron microscopy as well as thermogravimetric analysis, Raman, and x-ray diffraction. The in vitro release of 21 from the nanoparticles exhibited a controlled release profile just over one month following a burst release in the initial six hours and in addition to this a total release ratio of %50 and %85 were obtained at pH 7.4 and 5.5, respectively. 21-loaded PLGA nanoparticles displayed remarkably effective anticancer activity than 21. The IC50 values were determined as IC50 (21-loaded PLGA nanoparticles): 0.42 +/- 0.01 mg ml-1 and IC50 (free 21 molecule): 5.74 +/- 3.82 mg ml-1 against MCF-7 cells, and as IC50 (21-loaded PLGA nanoparticles): 0.77 +/- 0.12 mg ml-1 and IC50 (free 21 molecule): 1.32 +/- 0.31 mg ml-1 against HeLa cells after the incubation period of 24 h. Our findings indicated that triazole-substituted coumarins may be used as an anticancer agent by integrating them into a polymeric drug delivery system providing improved drug loading and effective controlled drug release. 2024-01-01T00:00:00Z https://hdl.handle.net/20.500.12294/4052 Aestheticization of fear and violence via public relations Önder Memiş, H. Burcu Fear is a human emotion that allows a person to survive. It has a function to ensure the continuity of life. The definition of fear has changed over time. Along with human development, transition to sedentary life, the industrial revolution, and modern life, fear and the things feared have changed. Fear has started to be marketed, especially in post-industrial societies. The governments have seen that fear and violence work to regulate, control, and passivate people. Political governments have had the unique opportunity to use fear as a mechanism for control and surveillance. The governments have aestheticized the fear and presented it indirectly with the support of media. The masses have been shaped as weak, scared, anxious, and helpless in the shadow of fear and violence. This study tries to shed light on the attempt to persuade the society about the legitimacy of the military government by presenting fear and violence to people in aestheticized forms in the 1980s in Turkey. © 2023, IGI Global. All rights reserved. 2022-01-01T00:00:00Z https://hdl.handle.net/20.500.12294/3995 THE BASICS OF FILMSCRIPT TRANSLATION AND POPULAR PRACTICES IN TURKEY Mencutekin, Mustafa The mainstream cinema sector and its fundamental element, films, have certainly become one of the prominent cornerstones of the globalization that has mostly been a matter of argumentation in academical circles in terms of its extent to be a factual civilization advance. in parallel to globalization programmes, the releasing rate of the films in other countries apart from the counry where the films are produced in a certain native Ianguage, has dramatically increased over the recent years compared to the rates in the past. That is to say, the number of the films addressing merely to the audience of the particular country of the production, today, has been rather scarce, compared to the films that are screened all over the world and may be modified as "global films". This process, likewise, has increased the significance of "subtitling and its translation". As far as Turkey is concerned, which is an eminent market country of the global / international cinema sector, the technique and popular applications of subtitling and its translation present a situation being rather far away from international measures and standards. 2009-01-01T00:00:00Z https://hdl.handle.net/20.500.12294/3843 Dijital Emek ve Kullanıcı İçeriğinin Metalaşması Katılımcı Sözlük Yazarları Üzerine İnceleme Duman, Kenan; Özdoyran, Güven İnternet teknolojileri ve sosyal medya uzun bir süredir toplumsal hayatın önemli bir parçasıdır. Sosyal medya araçlarında kullanıcıların faaliyetleri ve bunun internet ekonomisinde yeri dijital emek kavramı ile iş olarak görülmeyen üretim biçimleri içinde bir dizi duygusal ve sosyal aktiviteyi kapsar. Dijital emek, çevrimiçi medya için bilgi ve içerik oluşturulurken ödenmemiş emeğin sömürülmesi olarak tanımlanır. Bu çalışma, emek-dijital emek, “somut-soyut (maddi olmayan) meta karşıtlıklarını incelemeyi, bu türden maddi olmayan emek ve metaların niteliğini araştırmayı, dijital emek ve içerik üretim süreci üzerindeki etkisini ve olumlu/olumsuz yönlerini tartışmayı amaçlamaktadır. Bu amaç doğrultusunda, Türkiye’de katılımcı sözlüklerde yazan kullanıcılar ile yapılan derinlemesine görüşmelerin analizi ile sosyal medya kullanıcılarının eğilimlerinin neler olduğu ortaya konulmuştur. Sosyal ağlarda ve katılımcı sözlüklerdeki deneyimleri tartışarak bunun emek ile ilişkisi ve farkını açıklayan araştırmada ayrıca katılımcı sözlük yazarlarının kişisel verilerinin ikincil kullanımı hakkındaki düşünceleri de tespit edilmeye çalışılmıştır. Çalışma da özellikle kullanıcıların katılımcı sözlüklerde yazma ve çalışma süresini bir “mesai” olarak tanımlamamakta, bunu daha çok “eğlence” olarak gördükleri ortaya çıkmıştır. Ayrıca kullanıcıların katılımcı sözlüklerde geliştirdikleri aidiyet duygusu ve kimliğin önemi tespit edilmiştir. 2018-01-01T00:00:00Z