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dc.contributor.authorKurt-Celep, Inci
dc.contributor.authorZheleva-Dimitrova, Dimitrina
dc.contributor.authorSinan, Kouadio Ibrahime
dc.contributor.authorUba, Abdullahi Ibrahim
dc.date.accessioned2023-12-25T13:24:31Z
dc.date.available2023-12-25T13:24:31Z
dc.date.issued2023en_US
dc.identifier.citationKurt‐Celep, I., Zheleva‐Dimitrova, D., Sinan, K. I., Uba, A. I., Nilofar, Mahomoodally, M. F., ... & Zengin, G. (2023). Uncovering chemical profiles, biological potentials, and protection effect against ECM destruction in H2O2‐treated HDF cells of the extracts of Stachys tundjeliensis. Archiv der Pharmazie, e2300528.en_US
dc.identifier.urihttps://doi.org/10.1002/ardp.202300528
dc.identifier.urihttps://hdl.handle.net/20.500.12294/4003
dc.description.abstractThe genus Stachys L., one of the largest genera of the Lamiaceae family, is highly represented in Turkey. This study was conducted to determine the bio-pharmaceutical potential and phenolic contents of six different extracts from aerial parts of Stachys tundjeliensis. The obtained results showed that the ethanol extract exhibited the highest antioxidant activity in the antioxidant assays. Meanwhile, the ethanol extract displayed strong inhibitory activity against α-tyrosinase, the dichloromethane extract exhibited potent inhibition against butyrylcholinesterase, and the n-hexane extract against α-amylase. Based on ultra-high performance liquid chromatography coupled to high-resolution mass spectrometry analysis, more than 90 secondary metabolites, including hydroxybenzoic acid, hydroxycinnamic acid, and their glycosides, acylquinic acids, phenylethanoid glycosides, and various flavonoids were identified or tentatively annotated in the studied S. tundjeliensis extracts. It was observed that the application of S. tundjeliensis eliminated H2O2-induced oxidative stress. It was determined that protein levels of phospho-nuclear factor kappa B (NF-κB), receptor for advanced glycation endproducts, and activator protein-1, which are activated in the nucleus, decreased, and the synthesis of matrix metalloproteinase (MMP)-2 and MMP-9 also decreased to basal levels. Overall, these findings suggest that S. tundjeliensis contains diverse bioactive compounds for the development of nutraceuticals or functional foods with potent biological properties. © 2023 Deutsche Pharmazeutische Gesellschaft.en_US
dc.language.isoengen_US
dc.publisherJohn Wiley and Sons Incen_US
dc.relation.ispartofArchiv der Pharmazieen_US
dc.identifier.doi10.1002/ardp.202300528en_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAntioxidanten_US
dc.subjectEnzyme Inhibitionen_US
dc.subjectPhenolicsen_US
dc.subjectPhospho-NF-κBen_US
dc.subjectStachysen_US
dc.titleUncovering chemical profiles, biological potentials, and protection effect against ECM destruction in H2O2-treated HDF cells of the extracts of Stachys tundjeliensisen_US
dc.typearticleen_US
dc.departmentFen-Edebiyat Fakültesi, Moleküler Biyoloji ve Genetik Bölümüen_US
dc.authorid0000-0002-0853-108Xen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.institutionauthorUba, Abdullahi Ibrahim
dc.authorwosidP-3971-2019en_US
dc.authorscopusid57038704300en_US
dc.identifier.wosqualityQ2en_US
dc.identifier.wosWOS:001107056100001en_US
dc.identifier.scopus2-s2.0-85176951451en_US
dc.identifier.pmid37974540en_US


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