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dc.contributor.authorFawzi Mahomoodally, Mohamad
dc.contributor.authorZengin, Gokhan
dc.contributor.authorRoumita, Seebaluck-Sandoram
dc.contributor.authorCaprioli, Giovanni
dc.contributor.authorMustafa, Ahmed M.
dc.contributor.authorPiatti, Diletta
dc.contributor.authorYildiztugay, Evren
dc.contributor.authorAk, Gunes
dc.contributor.authorEsra Karadag, Ayse
dc.contributor.authorKhalid, Asaad
dc.contributor.authorAbdalla, Ashraf N.
dc.contributor.authorIbrahim Uba, Abdullahi
dc.contributor.authorDemirci, Fatih
dc.date.accessioned2023-05-02T11:17:40Z
dc.date.available2023-05-02T11:17:40Z
dc.date.issued2023en_US
dc.identifier.citationMahomoodally, M. F., Zengin, G., Roumita, S. S., Caprioli, G., Mustafa, A. M., Piatti, D., ... & Demirci, F. (2023). Chemical Characterization and Multidirectional Biological Effects of Different Solvent Extracts of Arum elongatum: in vitro and in silico Approaches. Chemistry & Biodiversity, e202201181.en_US
dc.identifier.issn1612-1872
dc.identifier.urihttps://doi.org/10.1002/cbdv.202201181
dc.identifier.urihttps://hdl.handle.net/20.500.12294/3810
dc.description.abstractArum elongatum (Araceae) is widely used traditionally for the treatment of abdominal pain, arterial hypertension, diabetes mellitus, rheumatism and hemorrhoids. This study investigated the antioxidant properties, individual phenolic compounds, total phenolic and total flavonoid contents (HPLC/MS analysis), reducing power and metal chelating effects of four extracts obtained from A. elongatum (ethyl acetate (EA), methanol (MeOH), methanol/water (MeOH/water) and infusion). The inhibitory activity of the extracts were also determined against acetylcholinesterase, butyrylcholinesterase, tyrosinase, amylase and glucosidase enzymes. The MeOH/water extracts contained the highest amount of phenolic contents (28.85 mg GAE/g) while the highest total flavonoid content was obtained with MeOH extract (36.77 mg RE/g). MeOH/water demonstrated highest antioxidant activity against DPPH center dot radical at 38.90 mg Trolox equivalent per gram. The infusion extract was the most active against ABTS(+center dot) (133.08 mg TE/g). MeOH/water extract showed the highest reducing abilities with the CUPRAC value of 102.22 mg TE/g and the FRAP value of 68.50 mg TE/g. A strong metal chelating effect was observed with MeOH/water extract (35.72 mg EDTAE/g). The PBD values of the extracts ranged from 1.01 to 2.17 mmol TE/g. EA extract displayed the highest inhibitory activity against AChE (2.32 mg GALAE/g), BChE (3.80 mg GALAE/g), alpha-amylase (0.56 mmol ACAE/g) and alpha-glucosidase (9.16 mmol ACAE/g) enzymes. Infusion extract was the most active against tyrosinase enzyme with a value of 83.33 mg KAE/g. A total of 28 compounds were identified from the different extracts. The compounds present in the highest concentration were chlorogenic acids, 4-hydroxybenzoic acid, caffeic acid, p-coumaric acid, ferulic acid, isoquercitrin, delphindin 3,5-diglucoside, kaempferol-3-glucoside and hyperoside. The biological activities of A. elongatum extracts could be due to the presence of compounds such as gallic acid, chlorogenic acids, ellagic acid, epicatechin, catechin, kaempferol, 4-hydroxybenzoic acid, caffeic acid, p-coumaric acid, ferulic acid, quercetin, isoquercitrin, and hyperoside. Extracts of A. elongatum showed promising biological activities which warrants further investigations in an endeavor to develop biopharmaceuticals.en_US
dc.language.isoengen_US
dc.publisherWILEY-V C H VERLAG GMBHen_US
dc.relation.ispartofCHEMISTRY & BIODIVERSITYen_US
dc.identifier.doi10.1002/cbdv.202201181en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectArumen_US
dc.subjectPhenolic Compositionen_US
dc.subjectBioactive Agenten_US
dc.subjectNatural Enzyme Inhibitorsen_US
dc.titleChemical Characterization and Multidirectional Biological Effects of Different Solvent Extracts of Arum elongatum: in Vitro and in Silico Approachesen_US
dc.typearticleen_US
dc.departmentFen-Edebiyat Fakültesi, Moleküler Biyoloji ve Genetik Bölümüen_US
dc.authorid0000-0002-0853-108Xen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.institutionauthorIbrahim Uba, Abdullahi
dc.authorwosidP-3971-2019en_US
dc.identifier.wosqualityQ3en_US
dc.identifier.wosWOS:000955552300001en_US


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