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dc.contributor.authorGhafour, Arash Adamnejaden_US
dc.contributor.authorÖdemiş, Demet Akdenizen_US
dc.contributor.authorTuncer, Şeref Buğraen_US
dc.contributor.authorKurt, Büşraen_US
dc.contributor.authorSaral, Mukaddes Avşaren_US
dc.contributor.authorErciyas, Seda Kılıçen_US
dc.contributor.authorErdoğan, Özge Şükrüoğluen_US
dc.contributor.authorÇelik, Betülen_US
dc.contributor.authorSaip, Pınaren_US
dc.contributor.authorYazıcı, Hülyaen_US
dc.date.accessioned2021-10-25T15:52:00Z
dc.date.available2021-10-25T15:52:00Z
dc.date.issued2021en_US
dc.identifier.citationGhafour, A. A., Odemis, D. A., Tuncer, S. B., Kurt, B., Saral, M. A., Erciyas, S. K., ... & Yazici, H. (2021). High expression level of miR-1260 family in the peripheral blood of patients with ovarian carcinoma. Journal of Ovarian Research, 14(1), 1-15.en_US
dc.identifier.urihttps://doi.org/10.1186/s13048-021-00878-x
dc.identifier.urihttps://hdl.handle.net/20.500.12294/2878
dc.description.abstractThe most common gynecologic cancers detected in women in Turkey are uterine cancer, ovarian cancer, and cervical cancer. These data reported that a mean of 3800 individuals were diagnosed with uterine cancer, 2790 were diagnosed with ovarian cancer, and 1950 were diagnosed with cervical cancer, and 400 individuals were diagnosed with other gynecologic cancers each year in Turkey. A mean of 14.270 individuals were detected to have been diagnosed with gynecologic cancers each year in the United States of America (USA). Ovarian cancer treatment is generally composed of chemotherapy, and surgery. In general, chemotherapy is administered after surgery. The identification of the molecular pathogenesis of ovarian cancer, and discovery of new moleculer biomarkers which facilitate the ovarian cancer treatment are required for an effective ovarian cancer treatment in clinics. miRNAs are reported to be the possible biologic indicators for various cancer types. We aimed to investigate 2 miRNAs which were suggested to have effect in ovarian cancer in our (previous) monozygotic twin study from miR-1260 microRNA family whose association with ovarian cancer yet has not been reported in the literature. We investigated the expression levels of miR-1260a, and miR-1260b miRNAs, in the peripheral blood lymphocytes of 150 familial and sporadic ovarian cancer patients, and of 100 healthy individuals of the control group who were matched for age, sex, and ethnicity with the patient group, and investigated their possible property of being a biologic indicator for ovarian cancer. The expression results of ovarian cancer patients were evaluated by comparison of the results of the control group in the study. The expression levels of miR-1260a, and miR-1260b in ovarian cancer patients were found highly increased compared with the levels in the control group. miR-1260a expression level in ovarian cancer patients was detected to have increased approximately 17 fold compared with the control group, and miR-1260b expression level in ovarian cancer patients was detected to have increased approximately 33 fold compared with the levels in the control group. The String Analyses showed that the miR-1260a was associated with the ribosomal protein family which was known to be effective in the translation stage of cell and that miR-1260b was associated with CHEK2 protein which was a member of the serine/threonine-protein kinase family. It should be investigated for larger cohorts in benign ovarian diseases and in different stages of patients receiving ovarian cancer treatment whether these two molecules are a noninvasive biomarker and therapeutic target to be used especially in the early diagnosis and prognosis of ovarian cancer in future.en_US
dc.language.isoengen_US
dc.publisherBMCen_US
dc.relation.ispartofJournal of Ovarian Researchen_US
dc.identifier.doi10.1186/s13048-021-00878-xen_US
dc.identifier.doi10.1186/s13048-021-00878-x
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.rightsAttribution-NoDerivs 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nd/3.0/us/*
dc.subjectFamilial and Sporadic Ovarian Canceren_US
dc.subjectmiRNA Expressionen_US
dc.subjectBiomarkeren_US
dc.titleHigh Expression Level of miR-1260 Family in the Peripheral Blood of Patients with Ovarian Carcinomaen_US
dc.typearticleen_US
dc.departmentTıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.identifier.volume14en_US
dc.identifier.issue1en_US
dc.identifier.startpage1en_US
dc.identifier.endpage15en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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