Yazar "Thornton, Julianne M." için listeleme
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Computational analysis of drug resistance of taxanes bound to human β-tubulin mutant (D26E)
Uba, Abdullahi Ibrahim; Bui-Linh, Candice; Thornton, Julianne M.; Olivieri, Michael; Wu, Chun (Elsevier Inc., 2023)The single-point mutation D26E in human β-tubulin is associated with drug resistance seen with two anti-mitotic taxanes (paclitaxel and docetaxel) when used to treat cancers. The molecular mechanism of this resistance ...