ORCID "0000-0002-0853-108X" Moleküler Biyoloji ve Genetik Bölümü / Department of Molecular Biology and Genetics için listeleme
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Integrating chemical analysis with in vitro, in silico, and network pharmacology to discover potential functional compounds from Marrubium astracanicum subsp. macrodon
Avsar, Omer Kaan; Kasbolat, Sevgi; Ak, Gunes; Nilofar; Caprioli, Giovanni; Santanatoglia, Agnese; Uysal, Ahmet; Uba, Abdullahi Ibrahim; Ponniya, Sathish Kumar M.; Paksoy, Mehmet Yavuz; Zengin, Gokhan (Elsevier B.V., 2024)The members of the genus Marrubium are of great interest because they contain biologically active compounds. With in this mind, we aimed to examine the chemical profiles and biological activities (antioxidant, enzyme ... -
Integration of chemical characterization, biological activities, and network pharmacology of different extracts from Syzygium rowlandii
Sinan, Kouadio Ibrahime; Sut, Stefania; Zengin, Gokhan; Dall'Acqua, Stefano; Bouyahya, Abdelhakim; Uba, Abdullahi Ibrahim; Ponniya, Sathish Kumar M.; Rengasamy, Kannan R. R. (ELSEVIER, 2024)The leaves and stem barks of Syzygium rowlandii, were considered as sources of biologically active compounds. Using the ultrasound-assisted extraction with different solvents, we obtained three types of extracts (ethyl ... -
LC-MS/MS and GC-MS profiling, antioxidant, enzyme inhibition, and antiproliferative activities of Thymus leucostomus HAUSSKN. & VELEN. extracts
Fayez, Shaimaa; Fahmy, Nouran M.; Zengin, Gokhan; Yagi, Sakina; Uba, Abdullahi Ibrahim; Eldahshan, Omayma A.; Koyuncu, Ismail; Temiz, Ebru; Dall'Acqua, Stefano; Sut, Stefania; Selvi, Selami (WILEY-V C H VERLAG GMBH, 2023)The chemical composition as well as antioxidant, antiproliferative, and enzyme inhibition activities of extracts from aerial parts of Thymus leucostomus H ausskn. & V elen. obtained with hexane, methanol, and water were ... -
Marine Streptomyces sp. PGC 39
Ahmad, Rabbia; Tousif, Muhammad Imran; Nazir, Mamona; Yaqoob, Asma; Shah, Syed Adnan Ali; Zengin, Gokhan; Uba, Abdullahi Ibrahim; Muhammad, Shabbir (Elsevier Ltd, 2024)Macrolidycin (1) and pyrachlomycin (2) were isolated from the culture broth of the marine bacterium Streptomyces sp. GSCWU 39. The isolates were characterized due to 1D and 2D-NMR spectral analyses and high resolution mass ... -
Phenolic compounds as histone deacetylase inhibitors: binding propensity and interaction insights from molecular docking and dynamics simulations
Uba, Abdullahi Ibrahim; Zengin, Gokhan (SPRINGER WIEN, 2023)Histone deacetylases are well-established target enzymes involved in the pathology of different diseases including cancer and neurodegenerative disorders. The approved HDAC inhibitor drugs are associated with cellular ... -
Phenolic compounds as potential adenosine deaminase inhibitors
Adenosine deaminase (ADA) is a Zn2+-containing enzyme that catalyzes the irreversible deamination of adenosine to inosine or deoxyadenosine to deoxyinosine. In addition to this enzymatic function, ADA mediates cell-to-cell ... -
Screening for Chemical Characterization and Pharmacological Properties of Different Extracts from Nepeta italica
Acquaviva, Alessandra; Di Simone, Simonetta Cristina; Nilofar, Abdelhakim; Bouyahya, Abdelhakim; Zengin, Gokhan; Recinella, Lucia; Leone, Sheila; Brunetti, Luigi; Uba, Abdullahi Ibrahim; Guler, Osman; Balos, Maruf; Cakilcioglu, Ugur; Menghini, Luigi; Ferrante, Claudio; Orlando, Giustino; Libero, Maria Loreta; Chiavaroli, Annalisa (Multidisciplinary Digital Publishing Institute (MDPI), 2023)Plants from the Nepeta genus have been proved to possess different pharmacological properties, among which are antimicrobial, antioxidant, anti-inflammatory, analgesic, and cytotoxic effects. Nepeta italica is a medicinal ... -
Uncovering chemical profiles, biological potentials, and protection effect against ECM destruction in H2O2-treated HDF cells of the extracts of Stachys tundjeliensis
Kurt-Celep, Inci; Zheleva-Dimitrova, Dimitrina; Sinan, Kouadio Ibrahime; Uba, Abdullahi Ibrahim (John Wiley and Sons Inc, 2023)The genus Stachys L., one of the largest genera of the Lamiaceae family, is highly represented in Turkey. This study was conducted to determine the bio-pharmaceutical potential and phenolic contents of six different extracts ... -
Unraveling the chemical profile, antioxidant, enzyme inhibitory, cytotoxic potential of different extracts from Astragalus caraganae
Kurt-Celep, Inci; Zengin, Gokhan; Uba, Abdullahi I.; Caprioli, Giovanni; Mustafa, Ahmed M.; Angeloni, Simone; Cakilcioglu, Ugur; Guler, Osman; Kaplan, Alevcan; Sharmeen, Jugreet; Mahomoodally, Mohamad F. (WILEY-V C H VERLAG GMBH, 2023)Six extracts (water, ethanol, ethanol-water, ethyl acetate, dichloromethane, and n-hexane) of Astragalus caraganae were studied for their biological activities and bioactive contents. Based on high-performance liquid ...