Show simple item record

dc.contributor.authorOymak, Yeşimen_US
dc.contributor.authorDodurga, Yavuzen_US
dc.contributor.authorTüredi, Ayşenen_US
dc.contributor.authorYaman, Yöntemen_US
dc.contributor.authorÖzek, Gülcihanen_US
dc.contributor.authorCartı, Özgüren_US
dc.contributor.authorTatlı Güneş, Burçaken_US
dc.contributor.authorErbudak, Esinen_US
dc.contributor.authorBerber, Ergülen_US
dc.contributor.authorBiray Avcı, Çığıren_US
dc.contributor.authorVergin, Cananen_US
dc.date.accessioned2016-03-17T14:34:19Z
dc.date.available2016-03-17T14:34:19Z
dc.date.issued2012
dc.identifier.citationOymak, Y.,Dodurga, Y., Turedi, A., Yaman, Y., Özek, G., Carti, Ö., Tatlı Güneş, B., Erbudak, E., Berber, E., Avcı, C.B., Vergin, C. (2012). Higher expression of the novel gene upregulated gene 4 in two acute lymphoblastic leukemia patients with poor prednisolone response. Acta Haematol. 128.2, 73-76.en_US
dc.identifier.issn0001-5792
dc.identifier.issn1421-9662
dc.identifier.urihttps://hdl.handle.net/20.500.12294/222
dc.identifier.urihttp://dx.doi.org/10.1159/000338220
dc.descriptionBerber, Ergül (Arel Author)en_US
dc.description.abstractElucidation of the molecular mechanisms of leukemogenesis is important for a better understanding of the prognosis of acute lymphoblastic leukemia (ALL). Studies have shown that the expression of upregulated gene 4 (URG4), which promotes cell growth and survival, is increased in different types of carcinomas including hepatocellular carcinoma, gastric cancer and osteosarcoma. Similarly, higher expression of URG4 and cyclin D1 gene might promote proliferation of the blast cells by causing escape from the G1 checkpoint and entry into the S phase. This study reports the high expression level of URG4 in 2 high-risk ALL patients for the first time in the literature. In conclusion, the higher expression of URG4 in our 2 patients suggests that URG4 might be involved in leukemogenesis. Future studies with a large number of highrisk ALL patients and cell culture studies are needed to demonstrate the exact role of URG4 in leukemogenesis.en_US
dc.language.isoengen_US
dc.publisherKargeren_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAcute Lymphoblastic Leukemiaen_US
dc.subjectLeukemogenesisen_US
dc.subjectPoor Prednisolone Responseen_US
dc.subjectURG4en_US
dc.titleHigher expression of the novel gene upregulated gene 4 in two acute lymphoblastic leukemia patients with poor prednisolone responseen_US
dc.typearticleen_US
dc.relation.journalActa Haematolen_US
dc.contributor.departmentİstanbul Arel Üniversitesi, Fen Edebiyat Fakültesi, Moleküler Biyoloji ve Genetik Bölümüen_US
dc.contributor.authorIDTR202783en_US
dc.contributor.authorIDTR41967en_US
dc.contributor.authorIDTR198849en_US
dc.contributor.authorIDTR51534en_US
dc.contributor.authorIDTR107619en_US
dc.identifier.volume128en_US
dc.identifier.issue2en_US
dc.identifier.startpage73en_US
dc.identifier.endpage76en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record