Erişim şekli için "info:eu-repo/semantics/openAccess" Moleküler Biyoloji ve Genetik Bölümü / Department of Molecular Biology and Genetics listeleme
Toplam kayıt 30, listelenen: 1-20
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Adding New Scientific Evidences on the Pharmaceutical Properties of Pelargonium quercetorum Agnew Extracts by Using In Vitro and In Silico Approaches
(MDPI, 2023)Pelargonium quercetorum is a medicinal plant traditionally used for treating intestinal worms. In the present study, the chemical composition and bio-pharmacological properties of P. quercetorum extracts were investigated. ... -
Aktif Bölge Mimarisinin Anlaşılması Temelinde, NAD + Bağımlı Mutant Candida methylica Format Dehidrogenaz Enziminin Spesifik Aktivitesinin Arttırılması
(TÜBİTAK KBAG Proje, 2023)Format dehidrogenaz enzimi (FDH), endüstriyel biyokatalizörler arasında son yıllarda en çok dikkat çeken enzimlerden biridir. Özellikle NAD(P)+ bağımlı FDH, gerçekleştirdiği reaksiyonun düşük redoks potansiyeli nedeniyle ... -
Bacteriophage genome engineering for phage therapy to combat bacterial antimicrobial resistance as an alternative to antibiotics
(SPRINGER, 2023)Bacteriophages (phages) are viruses that mainly infect bacteria and are ubiquitously distributed in nature, especially to their host. Phage engineering involves nucleic acids manipulation of phage genome for antimicrobial ... -
Bioactive agents from Parkia biglobosa (Jacq.) R.Br. ex G. Don bark extracts for health promotion and nutraceutical uses
(John Wiley and Sons Ltd, 2024)Background: Parkia biglobosa stem bark extracts were prepared using methanol, methanol 80%, water and ethyl acetate to investigate their phytochemical contents, as well as antioxidant and enzyme inhibitory properties.Results: ... -
Chemical characterization and biological abilities of Anthocleista djalonensis collected from two locations of Ivory Coast
(John Wiley and Sons Inc, 2023)In this study, the total phenolic and flavonoid contents, HPLC-DAD detected phytochemicals, antioxidant and enzyme inhibitory potential of methanolic and aqueous (as infusion) extracts of the medicinal plant, Anthocleista ... -
Chemical Characterization and Multidirectional Biological Effects of Different Solvent Extracts of Arum elongatum: in Vitro and in Silico Approaches
(WILEY-V C H VERLAG GMBH, 2023)Arum elongatum (Araceae) is widely used traditionally for the treatment of abdominal pain, arterial hypertension, diabetes mellitus, rheumatism and hemorrhoids. This study investigated the antioxidant properties, individual ... -
Comparison of Clinically Approved Molecules on SARS-CoV-2 Drug Target proteins: A Molecular Docking Study
(TUBITAK, 2021)The new type of coronavirus, SARS-CoV-2 has affected more than 22.6 million people worldwide. Since the first day the virus was spotted in Wuhan, China, numerous drug design studies have been conducted all over the globe. ... -
Computational investigation of influenza A virus M2 protein inhibition mechanism by ion channel blockers
(Scientific Technical Research Council Turkey-TUBITAK, 2019)The M2 protein of the influenza A virus, responsible for flu, is a homotetramer transmembrane protein, forming a transmembrane ion channel, where His 37s act as pH sensors and Trp 41s and Asp 44s act as channel gates. ... -
Elucidating the chemical profile and biological studies of Verbascum diversifolium Hochst. extracts
(Frontiers Media SA, 2024)The present study was designed to evaluate the chemical composition, antioxidant, enzyme inhibition and cytotoxic properties of different extracts from aerial parts of V. diversifolium (family Scrophulariaceae), a plant ... -
Epigenetics in Bladder Cancer: A Review of the Literature
(Kare Publishing, 2021)Bladder cancer (BC) is the 10th most frequent type of cancer worldwide, with around 549.000 new cases and 200.000 deaths/year and it has the highest incidence rates with a strong male and elderly predominance. Besides, BC ... -
Ex-Proof Materials and Regulations in Turkey
(STEF92 TECHNOLOGY LTD, 2014)Atmospheric Explosion is crucial point in occupational safety in modern industrilized economy. That is because ex-proof materials should be used in the explosive environments. Legistlation and governmental regulations aim ... -
Exploring the role of miRNAs in the diagnosis of MODY3
(TUBITAK, 2018)Background/aim: MODY3 associated with HNF1A is the most common form of MODY and is clinically misdiagnosed as type 1 diabetes due to similar clinical symptoms. This study aimed to analyze the role of HNF1A-regulated miRNAs ... -
Expression of genes related to iron homeostasis in breast cancer
(SPRINGER, 2023)Background The dysfunctions in the metabolism of iron have an important role in many pathological conditions, ranging from disease with iron deposition to cancer. Studies on malignant diseases of the breast reported irregular ... -
Functional characterisation of the type 1 von Willebrand disease candidate VWF gene variants: p. M771I, p. L881R and p. P1413L
(SIMTI Servizi, 2017)Background. Abnormalities in the biosynthetic pathway or increased clearance of plasma von Willebrand factor (VWF) are likely to contribute to decreased plasma VWF levels in inherited type 1 von Willebrand disease (VWD). ... -
Gene therapy in haemophilia: literature review and regional perspectives for Turkey
(SAGE Publications Ltd, 2022)Haemophilia is an X-linked lifelong congenital bleeding disorder that is caused by insufficient levels of factor VIII (FVIII; haemophilia A) or factor IX (FIX; haemophilia B) and characterized by spontaneous and trauma-related ... -
Genes and molecular mechanisms involved in the epileptogenesis of idiopathic absence epilepsies
(Elsevier, 2012)Idiopathic absence epilepsies (IAE), that have high prevalence particularly among children and adolescents, are complex disorders mainly caused by genetic factors. Childhood absence epilepsy and juvenile absence epilepsy ... -
Higher expression of the novel gene upregulated gene 4 in two acute lymphoblastic leukemia patients with poor prednisolone response
(Karger, 2012)Elucidation of the molecular mechanisms of leukemogenesis is important for a better understanding of the prognosis of acute lymphoblastic leukemia (ALL). Studies have shown that the expression of upregulated gene 4 (URG4), ... -
Highly stable and reusable immobilized formate dehydrogenases: Promising biocatalysts for in situ regeneration of NADH
(2016)This study aimed to prepare robust immobilized formate dehydrogenase (FDH) preparations which can be used as effective biocatalysts along with functional oxidoreductases, in which in situ regeneration of NADH is required. ... -
Improving of stability of formate dehydrogenase from candida methylica by immobilization onto eupergit C 250 L
(Pleiades Publishing, 2016)… -
In Silico Analysis of SARS-CoV-2 Spike Protein N501Y and N501T Mutation Effects on Human ACE2 Binding
(Elsevier Inc., 2022)The SARS-CoV-2 is an RNA-based virus and the most vital step of its survival is the attachment to hACE2 through its spike protein. Although SARS-CoV-2 has the ability to maintain high accurate replication and it can be ...