Başlık için Moleküler Biyoloji ve Genetik Bölümü / Department of Molecular Biology and Genetics listeleme
Toplam kayıt 71, listelenen: 35-54
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Higher expression of the novel gene upregulated gene 4 in two acute lymphoblastic leukemia patients with poor prednisolone response
(Karger, 2012)Elucidation of the molecular mechanisms of leukemogenesis is important for a better understanding of the prognosis of acute lymphoblastic leukemia (ALL). Studies have shown that the expression of upregulated gene 4 (URG4), ... -
Highly stable and reusable immobilized formate dehydrogenases: Promising biocatalysts for in situ regeneration of NADH
(2016)This study aimed to prepare robust immobilized formate dehydrogenase (FDH) preparations which can be used as effective biocatalysts along with functional oxidoreductases, in which in situ regeneration of NADH is required. ... -
HNF1A-MODY Mutations in Nuclear Localization Signal Impair HNF1A-Import Receptor KPNA6 Interactions
(Springer, 2021)Mutations in hepatocyte nuclear factor (HNF)1A gene cause the most common form of Maturity-onset diabetes of the young (MODY), a monogenic subtype of diabetes mellitus. Functional characterization of mutant proteins reveals ... -
Identification of novel vwf gene mutations in the Turkish type 2 VWD patient population
(Wiley Blackwell, 2015)… -
Improving of stability of formate dehydrogenase from candida methylica by immobilization onto eupergit C 250 L
(Pleiades Publishing, 2016)… -
In Silico Analysis of SARS-CoV-2 Spike Protein N501Y and N501T Mutation Effects on Human ACE2 Binding
(Elsevier Inc., 2022)The SARS-CoV-2 is an RNA-based virus and the most vital step of its survival is the attachment to hACE2 through its spike protein. Although SARS-CoV-2 has the ability to maintain high accurate replication and it can be ... -
In the quest for histone deacetylase inhibitors: current trends in the application of multilayered computational methods
(SPRINGER WIEN, 2023)Histone deacetylase (HDAC) inhibitors have gained attention over the past three decades because of their potential in the treatment of different diseases including various forms of cancers, neurodegenerative disorders, ... -
In Vitro and Molecular Docking Evaluation of Larvicidal Effects of Essential Oils of Five Aromatic Plants on the Fall Armyworm Spodoptera frugiperda JE. Smith (Lepidoptera: Noctuidae) from Ivory Coast
(WILEY-V C H VERLAG GMBH, 2023)Faced with the serious consequences resulting from the abusive and repeated use of synthetic chemicals, today rethinking crop protection is more than necessary. It is in this context that the essential oils of the Lamiaceae ... -
Integration of chemical characterization, biological activities, and network pharmacology of different extracts from Syzygium rowlandii
(ELSEVIER, 2024)The leaves and stem barks of Syzygium rowlandii, were considered as sources of biologically active compounds. Using the ultrasound-assisted extraction with different solvents, we obtained three types of extracts (ethyl ... -
İnsan p60-katanin Proteininin, Bitki RIC1 ve İnsan Homoloğu Kiaa1432 Proteinleri ile Etkileşiminin Tespiti & Etkileşimin Mikrotubuller Üzerinde Fonksiyonel Analizi
(TÜBİTAK KBAG Proje, 2023)Mikrotubuller ihtiyaç durumuna göre uzayıp–kısalabilen, yeniden organize olabilen dinamik yapılı polimerlerdir. Mikrotubul organizasyonu, bölünen hücrelerde mitoz, post-mitotik nöronlarda akson/dendrit yapılarının ... -
Lack of association of plasma factor XI with bleeding and report of two novel factor VII mutations
(Pergamon-Elsevier Science, 2016)7th International Eurasian Hematology Congress -
LC-MS/MS and GC-MS profiling, antioxidant, enzyme inhibition, and antiproliferative activities of Thymus leucostomus HAUSSKN. & VELEN. extracts
(WILEY-V C H VERLAG GMBH, 2023)The chemical composition as well as antioxidant, antiproliferative, and enzyme inhibition activities of extracts from aerial parts of Thymus leucostomus H ausskn. & V elen. obtained with hexane, methanol, and water were ... -
Marine Streptomyces sp. PGC 39
(Elsevier Ltd, 2024)Macrolidycin (1) and pyrachlomycin (2) were isolated from the culture broth of the marine bacterium Streptomyces sp. GSCWU 39. The isolates were characterized due to 1D and 2D-NMR spectral analyses and high resolution mass ... -
Mechanisms of peptide hydrolysis by aspartyl and metalloproteases
(Royal Society of Chemistry, 2016)Peptide hydrolysis has been involved in a wide range of biological, biotechnological, and industrial applications. In this perspective, the mechanisms of three distinct peptide bond cleaving enzymes, beta secretase (BACE1), ... -
The molecular genetics of von willebrand disease
(2012)Quantitative and/or qualitative deficiency of von Willebrand factor (vWF) is associated with the most common inherited bleeding disease von Willebrand disease (vWD). vWD is a complex disease with clinical and genetic ... -
Neuroprotective strategies against calpain-mediated neurodegeneration
(DOVE MEDICAL PRESS LTD, 2015)Calpains are calcium-dependent proteolytic enzymes that have deleterious effects on neurons upon their pathological over-activation. According to the results of numerous studies to date, there is no doubt that abnormal ... -
Novel N-(1-thia-4-azaspiro[4.5]decan-4-yl)carboxamide derivatives as potent and selective influenza virus fusion inhibitors
(Wiley, 2019)Hemagglutinin is the surface protein of the influenza virus that mediates both binding and penetration of the virus into host cells. We here report on the synthesis and structure-activity relationship of some novel ... -
De novo 8p23.1 deletion in a patient with absence epilepsy
(John Libbey Eurotext, 2017)The 8p23.1 deletion syndrome is a rare multisystem disorder with high penetrance and a variable phenotypic spectrum that includes congenital heart disease (CHD), intellectual disability, behavioural problems, microcephalia, ... -
Observation of the doubly Cabibbo-suppressed decays D + → K + π 0 π 0 and D + → K + π 0 η
(Springer Science and Business Media Deutschland GmbH, 2022)By analyzing e+e− annihilation data corresponding to an integrated luminosity of 2.93 fb−1 collected at the center-of-mass energy of 3.773 GeV with the BESIII detector, we report the first observations of the doubly ...
